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KMID : 0359819940230070783
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Journal of Korean Neurosurgical Society
1994 Volume.23 No. 7 p.783 ~ p.790
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Influence of Hypoglycemia and Hypothermia on Direct Current Potential During Cortical Spreading Depression in Rats
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문수현
박정율/박윤관/이기찬/구성화/이훈갑
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Abstract
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The object of this study was to investigate the influences of hypoglycemia and hypothermia on the direct current (DC) potential changes during cortical spreading depression (CSD) in rats. The induction of CSD was achieved by the application of
KCI
solution on the cortex of the frontal lobe. Hypoglycemia and hypothermia were induced respectively by insulin injection and the application of an ice pack. The DC potential changes during progressive hypoglycemia and hypothermia were measured
with
microelectrodes from the cortex of the parietal lobe of rats.
Under control condition, the rate of CSD was one per 5-10min and the negative shift of DC potential was about 30mV. The recovery time from negative shift to base line of DC potential was about 40sec.
In rats treated with insulin, the amplitude of DC potential shift was unaffected by hypoglycemia. The recovery time of DC shift was 40±2.26 sec at normoglycemia and it was delayed progressively as the blood glucose level lowered. The mean of it
was
63±8.02 sec at 30mg/dl and 77.1±22.0sec with the blood glucose falling below 20mg/dl.
The same delay in the recovery time as seen in the hypogylcemia group was observed in rats treated with hypothermia. The recovery time of DC shift was 39.4±3.02 sec in normothermia (36.5℃), but it was delayed to 61.15±4.15sec at 30℃ and
96.67±14.92sec at 26℃ body temperature.
This study suggested that each condition of profound hypoglycemia below 30mg/dl and hypothermia below 30℃ was to be harmful to the ion homeostasis and the integrity of the cell membrane and it may lead neurons to death.
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KEYWORD
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